Generowanie MostkÓW Disiarczkowych W BiaŁKach – RÓŻNorodnoŚĆ Strukturalna I Funkcjonalna BiaŁEk Dsba

نویسندگان

چکیده

Abstract Bacterial proteins of the Dsb (disulfide bond) system catalyze formation disulfide bridges, a post-translational modification extra-cytoplasmic proteins, which leads to stabilization their tertiary and quaternary structures often influences activity. DsbA – Escherichia coli monomeric oxidoreductase is best studied protein involved in this process. Recent rapid advances global analysis bacteria have thrown light on enormous diversity among bacterial systems. The set oxidative pathway, varies, depending microorganism. In article we focused characterization structural phylogenetic groups DsbAs. This review discuss physicochemical features interactions with redox partners as well substrate proteins. last part concentrates dimeric oxidoreductases responsible for generation. Many virulence factors are substrates Thus unraveling machinery that introduces bonds expanding knowledge about activities may facilitate discovery an effective anti-bacterial drugs. 1. Introduction. 2. system. 2.1. Characteristic E. thiol DsbA. 2.2. Izomerization / reduction pathway 3. Classification 3.1. Physicochemical different classes 4. partner substrates. 4.1. partner. 4.2. 5. Dimeric 6. Conclusions. 7. References

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ژورنال

عنوان ژورنال: Postepy Mikrobiologii

سال: 2021

ISSN: ['2545-3149', '0079-4252']

DOI: https://doi.org/10.21307/pm-2020.59.4.26